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Science 307 (5711): 858-859

Copyright © 2005 by the American Association for the Advancement of Science

Also see the archival list of Science's Compass: Enhanced Perspectives

Enhanced: Thymic Regulation--Hidden in Plain Sight

Ellen V. Rothenberg

The thymus is the nursery where T cell precursors mature into T cells of the alphabeta and gammadelta lineages. In a Perspective, Rothenberg discusses intriguing findings that reveal a new level of regulation in the thymus (Silva-Santos et al.). Apparently, double-positive T cells that are destined to mature into alphabeta T cells directly regulate the development of the gammadelta T-cell lineage through the production of lymphotoxin and the action of a transcription factor called RORgammat.

The author is in the Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA. E-mail: evroth{at}

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