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Science 307 (5714): 1422-1424

Copyright © 2005 by the American Association for the Advancement of Science

HIV: Experiencing the Pressures of Modern Life

David Nolan, Ian James, Simon Mallal

HIV/AIDS HIV, the wily virus that causes AIDS, is able to outwit any number of host immune defenses that it encounters during infection. However, as Nolan, James and Mallal discuss in their Perspective, there is increasing evidence that small pockets of individuals are relatively protected against HIV infection, and also experience less aggressive HIV disease progression, due to a fortuitous genetic barrier. The Perspective authors discuss the finding that a low copy number of the gene encoding CCL3L1, a ligand for CCR5 (the coreceptor that HIV must bind to for invasion of human T cells to proceed), can markedly alter HIV disease outcomes. The authors discuss the need to take into account genetic barriers like the CCR5-CCL3L1 network when developing vaccines against HIV.

The authors are at the Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Perth, Western Australia 6000, Australia. E-mail: S.Mallal{at}

Enhanced Detection of Human Immunodeficiency Virus Type 1 (HIV-1) Nef-Specific T Cells Recognizing Multiple Variants in Early HIV-1 Infection.
U. Malhotra, F. Li, J. Nolin, M. Allison, H. Zhao, J. I. Mullins, S. Self, and M. J. McElrath (2007)
J. Virol. 81, 5225-5237
   Abstract »    Full Text »    PDF »
Unusually High Frequency MHC Class I Alleles in Mauritian Origin Cynomolgus Macaques.
K. C. Krebs, Z. Jin, R. Rudersdorf, A. L. Hughes, and D. H. O'Connor (2005)
J. Immunol. 175, 5230-5239
   Abstract »    Full Text »    PDF »
Commentary: Sifting through the maze of viral and host diversity and HIV/AIDS clinical progression.
V. Miller (2005)
Int. J. Epidemiol. 34, 584-585
   Full Text »    PDF »
How HIV Performs Under Stress.
AIDS Clinical Care 2005, 7
   Full Text »

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