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Science 307 (5715): 1570-1572

Copyright © 2005 by the American Association for the Advancement of Science

Does Notch Take the Sweet Road to Success?

John B. Lowe

The cell surface receptor Notch is crucial for animal development, and elaborate mechanisms have evolved to control expression of the Notch gene. As Lowe describes in his Perspective, new work (Okajima et al.) now reveals that Notch can be regulated through control of its expression at the cell surface. It turns out that egress of Notch from its site of synthesis in the endoplasmic reticulum and its subsequent transit to the cell surface via the secretory pathway is modulated by the chaperone-like activity of a fucosyltransferase enzyme.

The author is at The Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, MI 48109-2216, USA. E-mail: johnlowe{at}

Golgi Glycosylation and Human Inherited Diseases.
H. H. Freeze and B. G. Ng (2011)
Cold Spring Harb Perspect Biol 3, a005371
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