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Science 307 (5715): 1572-1573

Copyright © 2005 by the American Association for the Advancement of Science

A New Mediator for an Old Hormone?

Sylvia Curtis Hewitt, Bonnie J. Deroo, Kenneth S. Korach

It is well established that estrogen mediates many of its physiological actions by binding to estrogen receptors in the nucleus, which then activate the transcription of target genes. However, as Hewitt, Deroo and Korach discuss in their Perspective, new work reveals that some of estrogen's effects may be mediated by a nonclassical pathway in which estrogen binds to non-estrogen receptor membrane proteins such as GPR30 (Revankar et al.).

The authors are at the Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. E-mail: korach{at}

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J. C. He, T.-C. Lu, M. Fleet, M. Sunamoto, M. Husain, W. Fang, S. Neves, Y. Chen, S. Shankland, R. Iyengar, et al. (2007)
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Gender Differences of Cardiovascular Disease: New Perspectives for Estrogen Receptor Signaling.
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