Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
SIGNAL TRANSDUCTION: A New Mediator for an Old Hormone?
Sylvia Curtis Hewitt, Bonnie J. Deroo, Kenneth S. Korach
It is well established that estrogen mediates many of its physiological actions by binding to estrogen receptors in the nucleus, which then activate the transcription of target genes. However, as Hewitt, Deroo and Korach discuss in their Perspective, new work reveals that some of estrogen's effects may be mediated by a nonclassical pathway in which estrogen binds to non-estrogen receptor membrane proteins such as GPR30 (Revankar et al.).
The authors are at the Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. E-mail: korach{at}niehs.nih.gov
The editors suggest the following Related Resources on Science sites:
In Science Magazine
REPORTS
Chetana M. Revankar, Daniel F. Cimino, Larry A. Sklar, Jeffrey B. Arterburn, and Eric R. Prossnitz (11 March 2005) Science307 (5715), 1625.
[DOI: 10.1126/science.1106943] |Abstract »|Full Text »|PDF »|Supporting Online Material »
Aldosterone stimulates vacuolar H+-ATPase activity in renal acid-secretory intercalated cells mainly via a protein kinase C-dependent pathway.
C. Winter, N. B. Kampik, L. Vedovelli, F. Rothenberger, T. G. Paunescu, P. A. Stehberger, D. Brown, H. John, and C. A. Wagner (2011)
Am J Physiol Cell Physiol
301, C1251-C1261
|Abstract »|Full Text »|PDF »
17{beta}-Estradiol: a novel hormone for improving immune and cardiovascular responses following trauma-hemorrhage.
17Beta-Estradiol Induces the Translocation of the Estrogen Receptors ESR1 and ESR2 to the Cell Membrane, MAPK3/1 Phosphorylation and Proliferation of Cultured Immature Rat Sertoli Cells.
T. F.G Lucas, E. R Siu, C. A Esteves, H. P Monteiro, C. A Oliveira, C. S Porto, and M. F. M Lazari (2008)
Biol Reprod
78, 101-114
|Abstract »|Full Text »|PDF »
Estrogen increases smooth muscle expression of {alpha}2C-adrenoceptors and cold-induced constriction of cutaneous arteries.
A. H. Eid, K. Maiti, S. Mitra, M. A. Chotani, S. Flavahan, S. R. Bailey, C. S. Thompson-Torgerson, and N. A. Flavahan (2007)
Am J Physiol Heart Circ Physiol
293, H1955-H1961
|Abstract »|Full Text »|PDF »
Activation of endothelial nitric oxide synthase by dietary isoflavones: Role of NO in Nrf2-mediated antioxidant gene expression.
G. E. Mann, D. J. Rowlands, F. Y.L. Li, P. de Winter, and R. C.M. Siow (2007)
Cardiovasc Res
75, 261-274
|Abstract »|Full Text »|PDF »
Retinoic Acid Inhibits HIV-1-Induced Podocyte Proliferation through the cAMP Pathway.
J. C. He, T.-C. Lu, M. Fleet, M. Sunamoto, M. Husain, W. Fang, S. Neves, Y. Chen, S. Shankland, R. Iyengar, et al. (2007)
J. Am. Soc. Nephrol.
18, 93-102
|Abstract »|Full Text »|PDF »
Gender Differences of Cardiovascular Disease: New Perspectives for Estrogen Receptor Signaling.
M. R. Meyer, E. Haas, and M. Barton (2006)
Hypertension
47, 1019-1026
|Full Text »|PDF »
17{beta}-Estradiol Induces Apoptosis in the Developing Rodent Prostate Independently of ER{alpha} or ER{beta}.
R. A Taylor, P. Cowin, J. F. Couse, K. S. Korach, and G. P. Risbridger (2006)
Endocrinology
147, 191-200
|Abstract »|Full Text »|PDF »
