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Science 308 (5718): 65-66

Copyright © 2005 by the American Association for the Advancement of Science

CELL BIOLOGY:
Kinasing and Clipping Down the NF-kappaB Trail

Nicolai S. C. van Oers and Zhijian J. Chen

Activation of T cells is a key requirement for a successful innate or adaptive immune response to pathogenic insult. T cell stimulation results in activation of the master transcription factor NF-kappaB by a complicated signaling pathway that is only partially understood. In their Perspective, van Oers and Chen discuss new findings that implicate the kinase PDK1 (Lee et al.) and a caspase (Su et al.) as crucial players in the T cell signaling pathway that activates NF-kappaB.


N. S. C. van Oers is in the Department of Microbiology and the Center for Immunology, and Z. J. Chen is in the Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. E-mail: zhijian.chen {at}utsouthwestern.edu


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Protein Kinase C-{delta} Negatively Regulates T Cell Receptor-induced NF-{kappa}B Activation by Inhibiting the Assembly of CARMA1 Signalosome.
Y. Liu, R. Song, Y. Gao, Y. Li, S. Wang, H.-Y. Liu, Y. Wang, Y.-H. Hu, and H.-B. Shu (2012)
J. Biol. Chem. 287, 20081-20087
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Cell sex: a new look at cell fate studies.
A. Maselli, P. Matarrese, E. Straface, S. Canu, F. Franconi, and W. Malorni (2009)
FASEB J 23, 978-984
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Physiologically high concentrations of 17beta-estradiol enhance NF-{kappa}B activity in human T cells.
S. Hirano, D. Furutama, and T. Hanafusa (2007)
Am J Physiol Regulatory Integrative Comp Physiol 292, R1465-R1471
   Abstract »    Full Text »    PDF »
Regulation and Function of IKK and IKK-Related Kinases.
H. Hacker and M. Karin (2006)
Sci. STKE 2006, re13
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Caspases leave the beaten track: caspase-mediated activation of NF-{kappa}B.
M. Lamkanfi, W. Declercq, T. Vanden Berghe, and P. Vandenabeele (2006)
J. Cell Biol. 173, 165-171
   Abstract »    Full Text »    PDF »
CARMA1 Is Required for Akt-Mediated NF-{kappa}B Activation in T Cells.
P. Narayan, B. Holt, R. Tosti, and L. P. Kane (2006)
Mol. Cell. Biol. 26, 2327-2336
   Abstract »    Full Text »    PDF »
PKC{beta} regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1.
H. Shinohara, T. Yasuda, Y. Aiba, H. Sanjo, M. Hamadate, H. Watarai, H. Sakurai, and T. Kurosaki (2005)
J. Exp. Med. 202, 1423-1431
   Abstract »    Full Text »    PDF »

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