Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 308 (5718): 65-66

Copyright © 2005 by the American Association for the Advancement of Science

Kinasing and Clipping Down the NF-kappaB Trail

Nicolai S. C. van Oers and Zhijian J. Chen

Activation of T cells is a key requirement for a successful innate or adaptive immune response to pathogenic insult. T cell stimulation results in activation of the master transcription factor NF-kappaB by a complicated signaling pathway that is only partially understood. In their Perspective, van Oers and Chen discuss new findings that implicate the kinase PDK1 (Lee et al.) and a caspase (Su et al.) as crucial players in the T cell signaling pathway that activates NF-kappaB.

N. S. C. van Oers is in the Department of Microbiology and the Center for Immunology, and Z. J. Chen is in the Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. E-mail: zhijian.chen {at}

Protein Kinase C-{delta} Negatively Regulates T Cell Receptor-induced NF-{kappa}B Activation by Inhibiting the Assembly of CARMA1 Signalosome.
Y. Liu, R. Song, Y. Gao, Y. Li, S. Wang, H.-Y. Liu, Y. Wang, Y.-H. Hu, and H.-B. Shu (2012)
J. Biol. Chem. 287, 20081-20087
   Abstract »    Full Text »    PDF »
Cell sex: a new look at cell fate studies.
A. Maselli, P. Matarrese, E. Straface, S. Canu, F. Franconi, and W. Malorni (2009)
FASEB J 23, 978-984
   Abstract »    Full Text »    PDF »
Physiologically high concentrations of 17beta-estradiol enhance NF-{kappa}B activity in human T cells.
S. Hirano, D. Furutama, and T. Hanafusa (2007)
Am J Physiol Regulatory Integrative Comp Physiol 292, R1465-R1471
   Abstract »    Full Text »    PDF »
Regulation and Function of IKK and IKK-Related Kinases.
H. Hacker and M. Karin (2006)
Sci. STKE 2006, re13
   Abstract »    Full Text »    PDF »
Caspases leave the beaten track: caspase-mediated activation of NF-{kappa}B.
M. Lamkanfi, W. Declercq, T. Vanden Berghe, and P. Vandenabeele (2006)
J. Cell Biol. 173, 165-171
   Abstract »    Full Text »    PDF »
CARMA1 Is Required for Akt-Mediated NF-{kappa}B Activation in T Cells.
P. Narayan, B. Holt, R. Tosti, and L. P. Kane (2006)
Mol. Cell. Biol. 26, 2327-2336
   Abstract »    Full Text »    PDF »
PKC{beta} regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1.
H. Shinohara, T. Yasuda, Y. Aiba, H. Sanjo, M. Hamadate, H. Watarai, H. Sakurai, and T. Kurosaki (2005)
J. Exp. Med. 202, 1423-1431
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882