Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 308 (5719): 209-210

Copyright © 2005 by the American Association for the Advancement of Science

"D" Is Not for Diversity

David N. Garboczi

Numerous antigens have been identified for B-cell receptors (antibodies) and for ab T-cell receptors. However, very few antigens have been identified that bind to the gammadelta TCRs expressed by gammadelta T cells. In a Perspective, Garboczi discusses two new structural studies (Shin et al., Adams et al.) that shed light on how gammadelta TCRs bind to one of their few known antigens, the MHC-like T22 molecule.

The author is in the Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, MD 20852, USA. E-mail: dgarboczi{at}

An evolutionarily mobile antigen receptor variable region gene: Doubly rearranging NAR-TcR genes in sharks.
M. F. Criscitiello, M. Saltis, and M. F. Flajnik (2006)
PNAS 103, 5036-5041
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882