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Science 308 (5719): 209-210

Copyright © 2005 by the American Association for the Advancement of Science

STRUCTURAL BIOLOGY:
"D" Is Not for Diversity

David N. Garboczi

Numerous antigens have been identified for B-cell receptors (antibodies) and for ab T-cell receptors. However, very few antigens have been identified that bind to the gammadelta TCRs expressed by gammadelta T cells. In a Perspective, Garboczi discusses two new structural studies (Shin et al., Adams et al.) that shed light on how gammadelta TCRs bind to one of their few known antigens, the MHC-like T22 molecule.


The author is in the Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, MD 20852, USA. E-mail: dgarboczi{at}niaid.nih.gov


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
An evolutionarily mobile antigen receptor variable region gene: Doubly rearranging NAR-TcR genes in sharks.
M. F. Criscitiello, M. Saltis, and M. F. Flajnik (2006)
PNAS 103, 5036-5041
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