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Numerous antigens have been identified for B-cell receptors (antibodies) and for ab T-cell receptors. However, very few antigens have been identified that bind to the TCRs expressed by T cells. In a Perspective, Garboczi discusses two new structural studies (Shin et al., Adams et al.) that shed light on how TCRs bind to one of their few known antigens, the MHC-like T22 molecule.
The author is in the Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, MD 20852, USA. E-mail: dgarboczi{at}niaid.nih.gov
The editors suggest the following Related Resources on Science sites:
Sunny Shin, Ramy El-Diwany, Steven Schaffert, Erin J. Adams, K. Christopher Garcia, Pablo Pereira, and Yueh-hsiu Chien (8 April 2005) Science308 (5719), 252.
[DOI: 10.1126/science.1106480] |Abstract »|Full Text »|PDF »|Supporting Online Material »
TCRs expressed by 
