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Science 308 (5720): 364-365

Copyright © 2005 by the American Association for the Advancement of Science

Of Grainy Heads and Broken Skins

Nicholas Harden

Many studies have revealed the signaling pathways and transcription factors involved in the reepithelialization of damaged epithelia, but less is known about the pathways involved in the repair of the outer layer of the surface barrier. In his Perspective, Harden discusses two new studies (Ting et al., Mace et al.) that reveal the part played by highly conserved members of the Grainy head transcription factor family in the repair of the surface-barrier outer layer of flies (the cuticle) and mice (the stratum corneum).

The author is in the Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, V5A 1S6 Canada. E-mail: nharden{at}

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882