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Science 308 (5721): 504-506

Copyright © 2005 by the American Association for the Advancement of Science

A Fishing Buddy for Hypothesis Generators

Roger Brent and Larry Lok

Understanding how signaling proteins interact in a giant intracellular network to control numerous cellular processes is the goal of many biologists. In their Perspective, Brent and Lok discuss a study that takes us a step closer to accomplishing this goal. The Perspective authors describe the application of Bayesian networks and computational methods to elucidating interactions among the signaling proteins in individual human T cells (Sachs et al.)

The authors are at the Molecular Sciences Institute, Berkeley, CA 94704, USA. E-mail: brent{at}, lok{at}

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882