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Science 308 (5721): 510-511

Copyright © 2005 by the American Association for the Advancement of Science

Also see the archival list of Science's Compass: Enhanced Perspectives

Enhanced: Guiding ATM to Broken DNA

Robert T. Abraham and Randal S. Tibbetts

Double-strand breaks induced in DNA by, for example, ionizing radiation are particularly dangerous to mammalian cells. Consequently, these cells depend on an elaborate repair machinery to execute swift and decisive repair of these double-strand breaks. A key player in this machinery is the serine-threonine kinase ATM. In their Perspective, Abraham and Tibbetts explore new insights into the protein complex responsible for detecting DNA double-strand breaks and then activating ATM (Lee et al.).

R. T. Abraham is in the Signal Transduction Program, The Burnham Institute, La Jolla, CA 92037, USA. E-mail: abraham{at} R. S. Tibbetts is in the Department of Pharmacology, University of Wisconsin-Madison, Madison, WI 53706, USA. E-mail: rstibbetts{at}

Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses.
N. Chiba, V. Comaills, B. Shiotani, F. Takahashi, T. Shimada, K. Tajima, D. Winokur, T. Hayashida, H. Willers, E. Brachtel, et al. (2012)
PNAS 109, 2760-2765
   Abstract »    Full Text »    PDF »
A Point Mutation in the Aspergillus nidulans sonBNup98 Nuclear Pore Complex Gene Causes Conditional DNA Damage Sensitivity.
C. P. C. De Souza, S. B. Hashmi, K. P. Horn, and S. A. Osmani (2006)
Genetics 174, 1881-1893
   Abstract »    Full Text »    PDF »
Deregulation of DNA Damage Signal Transduction by Herpesvirus Latency-Associated M2.
X. Liang, M. T. Pickering, N.-H. Cho, H. Chang, M. R. Volkert, T. F. Kowalik, and J. U. Jung (2006)
J. Virol. 80, 5862-5874
   Abstract »    Full Text »    PDF »

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