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Science 308 (5723): 801-803

Copyright © 2005 by the American Association for the Advancement of Science

Wnt Signaling Glows with RNAi

Eric R. Fearon and Ken M. Cadigan

Cellular signaling pathways such as the Wnt/Wingless pathway have traditionally been pieced together one step at a time. In a Perspective, Fearon and Cadigan discuss a new high-throughput screen in fruit fly cells that blocks the activity of nearly all fruit fly genes, one by one (DasGupta et al.). This study reveals 238 components of the Wnt/ Wingless pathway, including several proteins not previously known to operate in this pathway.

The authors are at the Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA; E. R. Fearon is also in the Departments of Internal Medicine, Human Genetics, and Pathology, and K. M. Cadigan is also in the Department of Molecular, Cellular, and Developmental Biology. E-mail: fearon{at}

Dishevelled 2 Signaling Promotes Self-Renewal and Tumorigenicity in Human Gliomas.
T. Pulvirenti, M. Van Der Heijden, L. A. Droms, J. T. Huse, V. Tabar, and A. Hall (2011)
Cancer Res. 71, 7280-7290
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