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Science 309 (5732): 252-253

Copyright © 2005 by the American Association for the Advancement of Science

Now Presenting: γδ T Cells

Robert L. Modlin and Peter A. Sieling

T lymphocytes of the immune system require that foreign molecules called antigens be presented to them for their clonal expansion and stimulation of their effector functions. Presentation of peptide antigens to activate naïve T cells was previously thought to reside solely in dendritic cells. A Perspective by Modlin and Sieling describes new evidence that challenges this premise. A population of T cells efficiently presents peptide antigens to alphabeta T cells, the predominant T cell population in mammals. This suggests that T cells function as part of innate (rapid, short-lived) and adaptive (slower, long-lasting) immunity, the two arms of the immune response.

The authors are in the Division of Dermatology and Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095, USA. E-mail: rmodlin{at}

Gamma/Delta T-Cell Functional Responses Differ after Pathogenic Human Immunodeficiency Virus and Nonpathogenic Simian Immunodeficiency Virus Infections.
D. A. Kosub, G. Lehrman, J. M. Milush, D. Zhou, E. Chacko, A. Leone, S. Gordon, G. Silvestri, J. G. Else, P. Keiser, et al. (2008)
J. Virol. 82, 1155-1165
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Virally Induced CD4+ T Cell Depletion Is Not Sufficient to Induce AIDS in a Natural Host.
J. M. Milush, J. D. Reeves, S. N. Gordon, D. Zhou, A. Muthukumar, D. A. Kosub, E. Chacko, L. D. Giavedoni, C. C. Ibegbu, K. S. Cole, et al. (2007)
J. Immunol. 179, 3047-3056
   Abstract »    Full Text »    PDF »
{gamma}{delta} T Cells Facilitate Adaptive Immunity against West Nile Virus Infection in Mice.
T. Wang, Y. Gao, E. Scully, C. T. Davis, J. F. Anderson, T. Welte, M. Ledizet, R. Koski, J. A. Madri, A. Barrett, et al. (2006)
J. Immunol. 177, 1825-1832
   Abstract »    Full Text »    PDF »

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