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Science 309 (5734): 568-569

Copyright © 2005 by the American Association for the Advancement of Science

Similar Is Different in Hippocampal Networks

György Buzsáki

Physiological evidence links the hippocampus to representation of the environment. However, nonspatial signals also activate hippocampal neurons. In his Perspective, Buzsáki discusses the proposal made by Leutgeb et al. that a dual coding scheme by hippocampal neurons handles this perplexing problem. The idea is based on observations of ensemble activity of hippocampal neurons in rats placed in either the same or different chambers and in the same or different rooms.

The author is at the Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA. E-mail: buzsaki{at}

Synaptic Kainate Receptors in CA1 Interneurons Gate the Threshold of Theta-Frequency-Induced Long-Term Potentiation.
V. R. J. Clarke, G. L. Collingridge, S. E. Lauri, and T. Taira (2012)
J. Neurosci. 32, 18215-18226
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