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DEVELOPMENTAL BIOLOGY: Rac1 Up for Epidermal Stem Cells
G. Paolo Dotto and George Cotsarelis
Stem cells in the skin and hair follicle are responsible for continual renewal of these tissues. Identification of genes involved in the proliferation and differentiation of stem cells is of paramount importance for understanding skin homeostasis and tumorigenesis. In their Perspective, Dotto and Cotsarelis discuss how the gene encoding Rac1 appears vital for maintaining the stem cells in the skin.
G. P. Dotto is at the Institute of Biochemistry, University of Lausanne, Chemin de Bovaresses 155, CH-1066 Epalinges, Switzerland, and the Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA. G. Cotsarelis is in the Department of Dermatology, Kligman Laboratories, University of Pennsylvania School of Medicine, M8 Stellar-Chance Building, 422 Curie Boulevard, Philadelphia, PA 19104, USA. E-mail: cotsarel{at}mail.med.upenn.edu
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Genes & Dev.
21, 562-577
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