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Science 309 (5741): 1682-1683

Copyright © 2005 by the American Association for the Advancement of Science

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Enhanced: Dietary Factors and Immunological Consequences

Timothy Hla

The lipid sphingosine 1-phosphate acts through cell surface receptors expressed on the surface of lymphocytes. In his Perspective, Hla discusses how the degradative action of sphingosine 1-phosphate lyase in tissues helps establish the steep vascular gradient of this lipid. Inhibition of the lyase by dietary factors disrupts the gradient, reducing T cell trafficking and thereby supressing immunity.

The author is at the Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA. E-mail: hla{at}

Dietary fatty acids modulate antigen presentation to hepatic NKT cells in nonalcoholic fatty liver disease.
J. Hua, X. Ma, T. Webb, J. J. Potter, M. Oelke, and Z. Li (2010)
J. Lipid Res. 51, 1696-1703
   Abstract »    Full Text »    PDF »
Sphingosine Kinase Type 2 Activation by ERK-mediated Phosphorylation.
N. C. Hait, A. Bellamy, S. Milstien, T. Kordula, and S. Spiegel (2007)
J. Biol. Chem. 282, 12058-12065
   Abstract »    Full Text »    PDF »
Polyunsaturated fatty acids, membrane organization, T cells, and antigen presentation.
S. R. Shaikh and M. Edidin (2006)
Am J Clin Nutr 84, 1277-1289
   Abstract »    Full Text »    PDF »

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