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IMMUNOLOGY: Enhanced: Dietary Factors and Immunological Consequences
Timothy Hla
The lipid sphingosine 1-phosphate acts through cell surface receptors expressed on the surface of lymphocytes. In his Perspective, Hla discusses how the degradative action of sphingosine 1-phosphate lyase in tissues helps establish the steep vascular gradient of this lipid. Inhibition of the lyase by dietary factors disrupts the gradient, reducing T cell trafficking and thereby supressing immunity.
The author is at the Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA. E-mail: hla{at}nso2.uchc.edu
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REPORTS
Susan R. Schwab, João P. Pereira, Mehrdad Matloubian, Ying Xu, Yong Huang, and Jason G. Cyster (9 September 2005) Science309 (5741), 1735.
[DOI: 10.1126/science.1113640] |Abstract »|Full Text »|PDF »|Supporting Online Material »
