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Science 309 (5741): 1682-1683

Copyright © 2005 by the American Association for the Advancement of Science

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IMMUNOLOGY:
Enhanced: Dietary Factors and Immunological Consequences

Timothy Hla

The lipid sphingosine 1-phosphate acts through cell surface receptors expressed on the surface of lymphocytes. In his Perspective, Hla discusses how the degradative action of sphingosine 1-phosphate lyase in tissues helps establish the steep vascular gradient of this lipid. Inhibition of the lyase by dietary factors disrupts the gradient, reducing T cell trafficking and thereby supressing immunity.


The author is at the Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA. E-mail: hla{at}nso2.uchc.edu


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