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Science 309 (5741): 1685-1686

Copyright © 2005 by the American Association for the Advancement of Science

APOPTOSIS:
p53 and PUMA: A Deadly Duo

Karen H. Vousden

The p53 tumor suppressor protein exhibits a number of activities that contribute to the induction of apoptosis. In her Perspective, Vousden discusses a study by Chipak et al. That describes how the nuclear and cytoplasmic functions of p53 can be elegantly brought together into the same pathway. This explains why both might be needed for the efficient induction of cell death.


The author is at the Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glagsow G61 1BD, UK. E-mail: k.vousden{at}beatson.gla.ac.uk


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Prolonged Expression of Puma in Cholinergic Amacrine Cells During the Development of Rat Retina.
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Physical and Functional Antagonism between Tumor Suppressor Protein p53 and Fortilin, an Anti-apoptotic Protein.
Y. Chen, T. Fujita, D. Zhang, H. Doan, D. Pinkaew, Z. Liu, J. Wu, Y. Koide, A. Chiu, C. C.-J. Lin, et al. (2011)
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Gene-specific repression of the p53 target gene PUMA via intragenic CTCF-Cohesin binding.
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W. Zhang, M. Konopleva, J. K. Burks, K. C. Dywer, W. D. Schober, J.-Y. Yang, T. J. McQueen, M.-C. Hung, and M. Andreeff (2010)
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The Ste20-like kinase SLK promotes p53 transactivation and apoptosis.
A. V. Cybulsky, T. Takano, J. Guillemette, J. Papillon, R. A. Volpini, and J. A. Di Battista (2009)
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Ex Vivo Simulation of the Action of Antileukemia Drugs by Measuring Apoptosis-Related mRNA in Blood.
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Outcomes of p53 activation - spoilt for choice.
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Transcriptional blackjack with p21..
A. Wood and A. Shilatifard (2006)
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