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Science 309 (5741): 1685-1686

Copyright © 2005 by the American Association for the Advancement of Science

p53 and PUMA: A Deadly Duo

Karen H. Vousden

The p53 tumor suppressor protein exhibits a number of activities that contribute to the induction of apoptosis. In her Perspective, Vousden discusses a study by Chipak et al. That describes how the nuclear and cytoplasmic functions of p53 can be elegantly brought together into the same pathway. This explains why both might be needed for the efficient induction of cell death.

The author is at the Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glagsow G61 1BD, UK. E-mail: k.vousden{at}

Rotavirus-Encoded Nonstructural Protein 1 Modulates Cellular Apoptotic Machinery by Targeting Tumor Suppressor Protein p53.
R. Bhowmick, U. C. Halder, S. Chattopadhyay, M. K. Nayak, and M. Chawla-Sarkar (2013)
J. Virol. 87, 6840-6850
   Abstract »    Full Text »    PDF »
Prolonged Expression of Puma in Cholinergic Amacrine Cells During the Development of Rat Retina.
T. Wakabayashi, J. Kosaka, T. Mori, and H. Yamada (2012)
Journal of Histochemistry & Cytochemistry 60, 777-788
   Abstract »    Full Text »    PDF »
Physical and Functional Antagonism between Tumor Suppressor Protein p53 and Fortilin, an Anti-apoptotic Protein.
Y. Chen, T. Fujita, D. Zhang, H. Doan, D. Pinkaew, Z. Liu, J. Wu, Y. Koide, A. Chiu, C. C.-J. Lin, et al. (2011)
J. Biol. Chem. 286, 32575-32585
   Abstract »    Full Text »    PDF »
Gene-specific repression of the p53 target gene PUMA via intragenic CTCF-Cohesin binding.
N. P. Gomes and J. M. Espinosa (2010)
Genes & Dev. 24, 1022-1034
   Abstract »    Full Text »    PDF »
Blockade of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase and Murine Double Minute Synergistically Induces Apoptosis in Acute Myeloid Leukemia via BH3-Only Proteins Puma and Bim.
W. Zhang, M. Konopleva, J. K. Burks, K. C. Dywer, W. D. Schober, J.-Y. Yang, T. J. McQueen, M.-C. Hung, and M. Andreeff (2010)
Cancer Res. 70, 2424-2434
   Abstract »    Full Text »    PDF »
The Ste20-like kinase SLK promotes p53 transactivation and apoptosis.
A. V. Cybulsky, T. Takano, J. Guillemette, J. Papillon, R. A. Volpini, and J. A. Di Battista (2009)
Am J Physiol Renal Physiol 297, F971-F980
   Abstract »    Full Text »    PDF »
Bendamustine Is Effective in p53-Deficient B-Cell Neoplasms and Requires Oxidative Stress and Caspase-Independent Signaling.
G. Roue, M. Lopez-Guerra, P. Milpied, P. Perez-Galan, N. Villamor, E. Montserrat, E. Campo, and D. Colomer (2008)
Clin. Cancer Res. 14, 6907-6915
   Abstract »    Full Text »    PDF »
Ex Vivo Simulation of the Action of Antileukemia Drugs by Measuring Apoptosis-Related mRNA in Blood.
M. Mitsuhashi, K. Endo, K. Obara, H. Izutsu, T. Ishida, N. Chikatsu, and A. Shinagawa (2008)
Clin. Chem. 54, 673-681
   Abstract »    Full Text »    PDF »
Granzyme B-induced Cell Death Involves Induction of p53 Tumor Suppressor Gene and Its Activation in Tumor Target Cells.
F. Meslin, J. Thiery, C. Richon, A. Jalil, and S. Chouaib (2007)
J. Biol. Chem. 282, 32991-32999
   Abstract »    Full Text »    PDF »
Enhanced Deacetylation of p53 by the Anti-apoptotic Protein HSCO in Association with Histone Deacetylase 1.
H. Higashitsuji, H. Higashitsuji, T. Masuda, Y. Liu, K. Itoh, and J. Fujita (2007)
J. Biol. Chem. 282, 13716-13725
   Abstract »    Full Text »    PDF »
Outcomes of p53 activation - spoilt for choice.
K. H. Vousden (2006)
J. Cell Sci. 119, 5015-5020
   Abstract »    Full Text »    PDF »
Transcriptional blackjack with p21..
A. Wood and A. Shilatifard (2006)
Genes & Dev. 20, 643-647
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