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Science 310 (5748): 630-631

Copyright © 2005 by the American Association for the Advancement of Science

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Enhanced: Less Steroids Make Bigger Flies

Kirst King-Jones and Carl S. Thummel

It has long been known that animal growth is achieved primarily during juvenile stages and terminates after sexual maturation. In their Perspective, King-Jones and Thummel discuss how the findings of Colombani et al. in this issue provide important new insights into how this coordination of growth and maturation is achieved through steroid and insulin signaling pathways.

The authors are in the Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA. E-mail: kirst{at}; carl.thummel{at}

Developmental Regulation of Glycolysis by 20-hydroxyecdysone and Juvenile Hormone in Fat Body Tissues of the Silkworm, Bombyx mori.
L. Tian, E. Guo, S. Wang, S. Liu, R.-J. Jiang, Y. Cao, E. Ling, and S. Li (2010)
J Mol Cell Biol 2, 255-263
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