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Science 310 (5751): 1124-1125

Copyright © 2005 by the American Association for the Advancement of Science

Twists in the Tale of the Aging Yeast

Jasper Rine

Aging limits the number of divisions available to cells and the chronological life span of nondividing cells. In his Perspective, Rine discusses recent findings that caloric restriction, SIR2, and its molecular cousins, play conserved roles in aging. However, expectations of a simple unified model linking caloric restriction and aging through Sir2 protein's NAD cofactor are now on hold.

The author is in the Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA. E-mail: jrine{at}

Whole lifespan microscopic observation of budding yeast aging through a microfluidic dissection platform.
S. S. Lee, I. A. Vizcarra, D. H. E. W. Huberts, L. P. Lee, and M. Heinemann (2012)
PNAS 109, 4916-4920
   Abstract »    Full Text »    PDF »
SIRT1: Linking Adaptive Cellular Responses to Aging-Associated Changes in Organismal Physiology..
D. Anastasiou and W. Krek (2006)
Physiology 21, 404-410
   Abstract »    Full Text »    PDF »

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