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Disrupted in schizophrenia 1 (DISC1), the first gene directly linked to schizophrenia, appears to regulate neuronal growth and migration. In their Perspective, Sawa and Snyder discuss the study by Millar et al. that reports the interaction of DISC1 with the enzyme phosphodiesterase 4B (PDE4B). PDE4B is now reported as aberrant in a schizophrenic family. The interaction of the two proteins controls PDE4B activity and may modulate mood and mentation both physiologically and pathophysiologically.
The authors are in the Departments of Psychiatry and Neuroscience and the Program in Cellular Molecular Medicine, and S. H. Snyder is also in the Department of Pharmacology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA. E-mail: asawa1{at}jhmi.edu; ssnyder{at}jhmi.edu
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In Science Magazine
REPORTS
J. Kirsty Millar, Benjamin S. Pickard, Shaun Mackie, Rachel James, Sheila Christie, Sebastienne R. Buchanan, M. Pat Malloy, Jennifer E. Chubb, Elaine Huston, George S. Baillie, Pippa A. Thomson, Elaine V. Hill, Nicholas J. Brandon, Jean-Christophe Rain, L. Miguel Camargo, Paul J. Whiting, Miles D. Houslay, Douglas H. R. Blackwood, Walter J. Muir, and David J. Porteous (18 November 2005) Science310 (5751), 1187.
[DOI: 10.1126/science.1112915] |Abstract »|Full Text »|PDF »|Supporting Online Material »
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