Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 310 (5751): 1128-1129

Copyright © 2005 by the American Association for the Advancement of Science

Two Genes Link Two Distinct Psychoses

Akira Sawa and Solomon H. Snyder

Disrupted in schizophrenia 1 (DISC1), the first gene directly linked to schizophrenia, appears to regulate neuronal growth and migration. In their Perspective, Sawa and Snyder discuss the study by Millar et al. that reports the interaction of DISC1 with the enzyme phosphodiesterase 4B (PDE4B). PDE4B is now reported as aberrant in a schizophrenic family. The interaction of the two proteins controls PDE4B activity and may modulate mood and mentation both physiologically and pathophysiologically.

The authors are in the Departments of Psychiatry and Neuroscience and the Program in Cellular Molecular Medicine, and S. H. Snyder is also in the Department of Pharmacology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA. E-mail: asawa1{at}; ssnyder{at}

Molecular Characterization of Disrupted in Schizophrenia-1 Risk Variant S704C Reveals the Formation of Altered Oligomeric Assembly.
S. Narayanan, H. Arthanari, M. S. Wolfe, and G. Wagner (2011)
J. Biol. Chem. 286, 44266-44276
   Abstract »    Full Text »    PDF »
DISC1 in Schizophrenia: Genetic Mouse Models and Human Genomic Imaging.
M. Johnstone, P. A. Thomson, J. Hall, A. M. McIntosh, S. M. Lawrie, and D. J. Porteous (2011)
Schizophr Bull 37, 14-20
   Abstract »    Full Text »    PDF »
Review of Pathological Hallmarks of Schizophrenia: Comparison of Genetic Models With Patients and Nongenetic Models.
H. Jaaro-Peled, Y. Ayhan, M. V. Pletnikov, and A. Sawa (2010)
Schizophr Bull 36, 301-313
   Abstract »    Full Text »    PDF »
NMDA Receptor Phosphorylation at a Site Affected in Schizophrenia Controls Synaptic and Behavioral Plasticity.
B. Li, N. Devidze, D. Barengolts, N. Prostak, E. Sphicas, A. J. Apicella, R. Malinow, and E. S. Emamian (2009)
J. Neurosci. 29, 11965-11972
   Abstract »    Full Text »    PDF »
Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans.
T. Hikida, H. Jaaro-Peled, S. Seshadri, K. Oishi, C. Hookway, S. Kong, D. Wu, R. Xue, M. Andrade, S. Tankou, et al. (2007)
PNAS 104, 14501-14506
   Abstract »    Full Text »    PDF »
DISC1 Regulates the Transport of the NUDEL/LIS1/14-3-3{varepsilon} Complex through Kinesin-1.
S. Taya, T. Shinoda, D. Tsuboi, J. Asaki, K. Nagai, T. Hikita, S. Kuroda, K. Kuroda, M. Shimizu, S. Hirotsune, et al. (2007)
J. Neurosci. 27, 15-26
   Abstract »    Full Text »    PDF »
Schizophrenia in Translation: Disrupted in Schizophrenia (DISC1): Integrating Clinical and Basic Findings.
R. C. Roberts (2007)
Schizophr Bull 33, 11-15
   Abstract »    Full Text »    PDF »
DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1.
A. Kamiya, T. Tomoda, J. Chang, M. Takaki, C. Zhan, M. Morita, M. B. Cascio, S. Elashvili, H. Koizumi, Y. Takanezawa, et al. (2006)
Hum. Mol. Genet. 15, 3313-3323
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882