Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 310 (5752): 1288-1289

Copyright © 2005 by the American Association for the Advancement of Science

Enhanced: Encountering MicroRNAs in Cell Fate Signaling

Xantha Karp and Victor Ambros

The recent discovery of short regulatory RNAs called microRNAs has expanded our understanding of the regulation of gene expression, yet little is known about the role of microRNAs in developmental signaling pathways. In their Perspective, Karp and Ambros discuss a new study by Yoo and Greenwald that finds a microRNA to be a direct target of LIN-12/Notch signaling. This influences cell fate decisions during C. elegans development and may extend to other organisms, because the Notch signaling pathway is highly conserved.

The authors are in the Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA. E-mail: victor.r.ambros{at}; xantha.e.karp{at}

miR-338-3p Suppresses Gastric Cancer Progression through a PTEN-AKT Axis by Targeting P-REX2a.
B. Guo, L. Liu, J. Yao, R. Ma, D. Chang, Z. Li, T. Song, and C. Huang (2014)
Mol. Cancer Res. 12, 313-321
   Abstract »    Full Text »    PDF »
Combined Serum CA19-9 and miR-27a-3p in Peripheral Blood Mononuclear Cells to Diagnose Pancreatic Cancer.
W.-S. Wang, L.-X. Liu, G.-P. Li, Y. Chen, C.-Y. Li, D.-Y. Jin, and X.-L. Wang (2013)
Cancer Prevention Research 6, 331-338
   Abstract »    Full Text »    PDF »
miRCancer: a microRNA-cancer association database constructed by text mining on literature.
B. Xie, Q. Ding, H. Han, and D. Wu (2013)
Bioinformatics 29, 638-644
   Abstract »    Full Text »    PDF »
Increased miR-708 Expression in NSCLC and Its Association with Poor Survival in Lung Adenocarcinoma from Never Smokers.
J. S. Jang, H.-S. Jeon, Z. Sun, M. C. Aubry, H. Tang, C.-H. Park, F. Rakhshan, D. A. Schultz, C. P. Kolbert, R. Lupu, et al. (2012)
Clin. Cancer Res. 18, 3658-3667
   Abstract »    Full Text »    PDF »
Drosophila miR-124 regulates neuroblast proliferation through its target anachronism.
R. Weng and S. M. Cohen (2012)
Development 139, 1427-1434
   Abstract »    Full Text »    PDF »
Camptothecin Induces Apoptosis in Cancer Cells via MicroRNA-125b-Mediated Mitochondrial Pathways.
C.-W. Zeng, X.-J. Zhang, K.-Y. Lin, H. Ye, S.-Y. Feng, H. Zhang, and Y.-Q. Chen (2012)
Mol. Pharmacol. 81, 578-586
   Abstract »    Full Text »    PDF »
MiR-637 maintains the balance between adipocytes and osteoblasts by directly targeting Osterix.
J.-f. Zhang, W.-m. Fu, M.-l. He, H. Wang, W.-m. Wang, S.-c. Yu, X.-W. Bian, J. Zhou, M. C. M. Lin, G. Lu, et al. (2011)
Mol. Biol. Cell 22, 3955-3961
   Abstract »    Full Text »    PDF »
Prioritizing Candidate Disease miRNAs by Topological Features in the miRNA Target-Dysregulated Network: Case Study of Prostate Cancer.
J. Xu, C.-X. Li, J.-Y. Lv, Y.-S. Li, Y. Xiao, T.-T. Shao, X. Huo, X. Li, Y. Zou, Q.-L. Han, et al. (2011)
Mol. Cancer Ther. 10, 1857-1866
   Abstract »    Full Text »    PDF »
Chemoprevention of Cigarette Smoke-Induced Alterations of MicroRNA Expression in Rat Lungs.
A. Izzotti, G. A. Calin, V. E. Steele, C. Cartiglia, M. Longobardi, C. M. Croce, and S. De Flora (2010)
Cancer Prevention Research 3, 62-72
   Abstract »    Full Text »    PDF »
Executing multicellular differentiation: quantitative predictive modelling of C.elegans vulval development.
N. Bonzanni, E. Krepska, K. A. Feenstra, W. Fokkink, T. Kielmann, H. Bal, and J. Heringa (2009)
Bioinformatics 25, 2049-2056
   Abstract »    Full Text »    PDF »
Downregulation of microRNA expression in the lungs of rats exposed to cigarette smoke.
A. Izzotti, G. A. Calin, P. Arrigo, V. E. Steele, C. M. Croce, and S. De Flora (2009)
FASEB J 23, 806-812
   Abstract »    Full Text »    PDF »
Ethanol exposure induces differential microRNA and target gene expression and teratogenic effects which can be suppressed by folic acid supplementation.
L.-L. Wang, Z. Zhang, Q. Li, R. Yang, X. Pei, Y. Xu, J. Wang, S.-F. Zhou, and Y. Li (2009)
Hum. Reprod. 24, 562-579
   Abstract »    Full Text »    PDF »
UCbase & miRfunc: a database of ultraconserved sequences and microRNA function.
C. Taccioli, E. Fabbri, R. Visone, S. Volinia, G. A. Calin, L. Y. Fong, R. Gambari, A. Bottoni, M. Acunzo, J. Hagan, et al. (2009)
Nucleic Acids Res. 37, D41-D48
   Abstract »    Full Text »    PDF »
A MicroRNA Signature of Hypoxia.
R. Kulshreshtha, M. Ferracin, S. E. Wojcik, R. Garzon, H. Alder, F. J. Agosto-Perez, R. Davuluri, C.-G. Liu, C. M. Croce, M. Negrini, et al. (2007)
Mol. Cell. Biol. 27, 1859-1867
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882