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Science 310 (5753): 1442-1443

Copyright © 2005 by the American Association for the Advancement of Science

IMMUNOLOGY:
Tipping the Scales Toward More Effective Antibodies

Jenny M. Woof

Immunoglobulin G molecules, key mediators of immune protection and burgeoning therapeutic reagents, exist in different forms or subclasses. In her Perspective, Woof discusses new work by Nimmerjahn and Ravetch that reveals how, in some settings, the in vivo functional capabilities of each subclass may be predicted on the basis of differential interaction with specific cellular Fc receptors.


The author is in the Division of Pathology and Neuroscience, University of Dundee Medical School, Ninewells Hospital, Dundee DD1 9SY, UK. E-mail: j.m.woof{at}dundee.ac.uk


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Blood 112, 2390-2399
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Complement-Dependent Tumor Cell Lysis Triggered by Combinations of Epidermal Growth Factor Receptor Antibodies.
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Cancer Res. 68, 4998-5003
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Effector Mechanisms of Recombinant IgA Antibodies against Epidermal Growth Factor Receptor.
M. Dechant, T. Beyer, T. Schneider-Merck, W. Weisner, M. Peipp, J. G. J. van de Winkel, and T. Valerius (2007)
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