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Science 310 (5753): 1443-1444

Copyright © 2005 by the American Association for the Advancement of Science

Keeping Survivin Nimble at Centromeres in Mitosis

William C. Earnshaw

Ubiquitin is well known as a grim reaper that marks proteins for destruction. In his Perspective, Earnshaw discusses a study by Vong et al. that reports a new aspect of ubiquitin function--regulation of the dynamic behavior of the chromosomal passenger protein survivin during mitosis. If survivin carries either too little or too much polyubiquitin, survivin dynamics at centromeres are perturbed, and chromosome segregation is disrupted.

The author is at the Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK. E-mail: bill.earnshaw{at}

The Survivin-Crm1 interaction is essential for chromosomal passenger complex localization and function.
S. K. Knauer, C. Bier, N. Habtemichael, and R. H. Stauber (2006)
EMBO Rep. 7, 1259-1265
   Abstract »    Full Text »    PDF »
Global analysis of the human gastric epithelial transcriptome altered by Helicobacter pylori eradication in vivo.
M B Resnick, E Sabo, P A Meitner, S S Kim, Y Cho, H K Kim, R Tavares, and S F Moss (2006)
Gut 55, 1717-1724
   Abstract »    Full Text »    PDF »
Carcinogenesis and apoptosis: paradigms and paradoxes.
B. Zhivotovsky and S. Orrenius (2006)
Carcinogenesis 27, 1939-1945
   Abstract »    Full Text »    PDF »
Regulation of Survivin Stability by the Aryl Hydrocarbon Receptor-interacting Protein.
B. H. Kang and D. C. Altieri (2006)
J. Biol. Chem. 281, 24721-24727
   Abstract »    Full Text »    PDF »

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