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Science 310 (5753): 1443-1444

Copyright © 2005 by the American Association for the Advancement of Science

CELL BIOLOGY:
Keeping Survivin Nimble at Centromeres in Mitosis

William C. Earnshaw

Ubiquitin is well known as a grim reaper that marks proteins for destruction. In his Perspective, Earnshaw discusses a study by Vong et al. that reports a new aspect of ubiquitin function--regulation of the dynamic behavior of the chromosomal passenger protein survivin during mitosis. If survivin carries either too little or too much polyubiquitin, survivin dynamics at centromeres are perturbed, and chromosome segregation is disrupted.


The author is at the Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK. E-mail: bill.earnshaw{at}ed.ac.uk


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