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Science 310 (5756): 1911-1913

Copyright © 2005 by the American Association for the Advancement of Science

The Tick-Tock of Aging?

Adam Antebi

lin-4, an evolutionarily conserved microRNA, and its regulatory target lin-14, encoding a nuclear protein, constitute a biological timing mechanism that advances Caenorhabditis elegans larval development. In his Perspective, Antebi discusses the report by Boehm and Slack that shows how these components may also regulate adult longevity. The microRNA and its target may work through DAF-16/FOXO, a forkhead transcription factor that extends life in diverse species. Hence, biological timers may regulate aging.

The author is at the Huffington Center on Aging, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. E-mail: aantebi{at}

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882