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Depression has long been linked to a defect in signals elicited by the neurotransmitter serotonin. This may be due to a deficit of a key protein in the brain that makes receptors for serotonin available for action.
The author is in the Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK. E-mail: trevor.sharp{at}pharm.ox.ac.uk
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[DOI: 10.1126/science.1117571] |Abstract »|Full Text »|PDF »|Supporting Online Material »