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Science 311 (5762): 789-790

Copyright © 2006 by the American Association for the Advancement of Science

A Sophisticated Scaffold Wields a New Trick

Ashton Breitkreutz and Mike Tyers

Many cellular processes are governed by proteins that are docked onto a scaffold protein. In addition to providing binding sites, scaffolds influence the signaling output of these multiprotein complexes.

A. Breitkreutz is with the Campbell Family Institute for Breast Cancer Research, Toronto Medical Discovery Tower, Toronto, Canada M5G 1L7. E-mail: abreitkr{at} M. Tyers is at the Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, Toronto, Canada M5G 1X5. E-mail: tyers{at}

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882