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Science 311 (5764): 1110-1111

Copyright © 2006 by the American Association for the Advancement of Science

The Stress of Finding NEMO

Jiri Bartek and Jiri Lukas

A cell's response to damaged DNA is triggered when two proteins leave the nucleus and converge upon a signaling complex in the cytoplasm. This activates a key transcription factor that then moves into the nucleus to promote cell survival.

The authors are at the Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark. E-mail: jb{at}

Histone Deacetylase Inhibitors Activate NF-{kappa}B in Human Leukemia Cells through an ATM/NEMO-related Pathway.
R. R. Rosato, S. S. Kolla, S. K. Hock, J. A. Almenara, A. Patel, S. Amin, P. Atadja, P. B. Fisher, P. Dent, and S. Grant (2010)
J. Biol. Chem. 285, 10064-10077
   Abstract »    Full Text »    PDF »
The Spindle Positioning Protein Kar9p Interacts With the Sumoylation Machinery in Saccharomyces cerevisiae.
N. Meednu, H. Hoops, S. D'Silva, L. Pogorzala, S. Wood, D. Farkas, M. Sorrentino, E. Sia, P. Meluh, and R. K. Miller (2008)
Genetics 180, 2033-2055
   Abstract »    Full Text »    PDF »
Novel Mechanism whereby Nuclear Factor {kappa}B Mediates DNA Damage Repair through Regulation of O6-Methylguanine-DNA-Methyltransferase.
I. Lavon, D. Fuchs, D. Zrihan, G. Efroni, B. Zelikovitch, Y. Fellig, and T. Siegal (2007)
Cancer Res. 67, 8952-8959
   Abstract »    Full Text »    PDF »
Review: Ubiquitination and de-ubiquitination: role in regulation of signaling by Toll-like receptors.
E. L. Lowe, T. M. Doherty, H. Karahashi, and M. Arditi (2006)
Innate Immunity 12, 337-345
   Abstract »    PDF »

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