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Science 311 (5764): 1110-1111

Copyright © 2006 by the American Association for the Advancement of Science

CELL BIOLOGY:
The Stress of Finding NEMO

Jiri Bartek and Jiri Lukas

A cell's response to damaged DNA is triggered when two proteins leave the nucleus and converge upon a signaling complex in the cytoplasm. This activates a key transcription factor that then moves into the nucleus to promote cell survival.


The authors are at the Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark. E-mail: jb{at}cancer.dk


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I. Lavon, D. Fuchs, D. Zrihan, G. Efroni, B. Zelikovitch, Y. Fellig, and T. Siegal (2007)
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Review: Ubiquitination and de-ubiquitination: role in regulation of signaling by Toll-like receptors.
E. L. Lowe, T. M. Doherty, H. Karahashi, and M. Arditi (2006)
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