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The immune effect of a cytokine bound to an antibody is paradoxically much stronger than that of the cytokine alone, suggesting a way to lower therapeutic doses and thereby reduce side effects.
The authors are in the Department of Immunology and the Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195-7370, USA. E-mail: mprlic{at}u.washington.edu, mbevan{at}u.washington.edu
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