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Science 311 (5769): 1875-1876

Copyright © 2006 by the American Association for the Advancement of Science

IMMUNOLOGY:
An Antibody Paradox, Resolved

Martin Prlic and Michael J. Bevan

The immune effect of a cytokine bound to an antibody is paradoxically much stronger than that of the cytokine alone, suggesting a way to lower therapeutic doses and thereby reduce side effects.


The authors are in the Department of Immunology and the Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195-7370, USA. E-mail: mprlic{at}u.washington.edu, mbevan{at}u.washington.edu


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