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Science 311 (5769): 1875-1876

Copyright © 2006 by the American Association for the Advancement of Science

An Antibody Paradox, Resolved

Martin Prlic and Michael J. Bevan

The immune effect of a cytokine bound to an antibody is paradoxically much stronger than that of the cytokine alone, suggesting a way to lower therapeutic doses and thereby reduce side effects.

The authors are in the Department of Immunology and the Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195-7370, USA. E-mail: mprlic{at}, mbevan{at}

Rapid generation of a functional NK-cell compartment.
M. Prlic, D. Kamimura, and M. J. Bevan (2007)
Blood 110, 2024-2026
   Abstract »    Full Text »    PDF »
Neutralizing antibodies in multiple sclerosis: a complex impact on interferon responses, magnetic resonance imaging findings and clinical outcomes.
A.T. Reder (2007)
Multiple Sclerosis Journal 13, 53-62
   Abstract »    PDF »

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