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Science 312 (5770): 61-63

Copyright © 2006 by the American Association for the Advancement of Science

Reducible Complexity

Christoph Adami

How does biological complexity arise? The molecular evolution of two hormone receptors was traced from a common ancestral receptor. Through a series of mutations, receptors with distinct hormone binding properties evolved, one before the appearance of its cognate ligand.

The author is at the Keck Graduate Institute of Applied Life Sciences, Claremont, CA 91711, USA. E-mail: adami{at}

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882