Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 312 (5772): 377-378

Copyright © 2006 by the American Association for the Advancement of Science

Hitting the Hot Spots of Cell Signaling Cascades

John Joseph Grubb Tesmer

Small-molecule inhibitors can bind in several different ways to protein interaction sites on signaling proteins, thereby selecting downstream pathways. This type of targeting may be useful therapeutically.

The author is in the Department of Pharmacology, Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109, USA. E-mail: tesmerjj{at}

Peptide Inhibitors Disrupt the Serotonin 5-HT2C Receptor Interaction with Phosphatase and Tensin Homolog to Allosterically Modulate Cellular Signaling and Behavior.
N. C. Anastasio, S. R. Gilbertson, M. J. Bubar, A. Agarkov, S. J. Stutz, Y. Jeng, N. M. Bremer, T. D. Smith, R. G. Fox, S. E. Swinford, et al. (2013)
J. Neurosci. 33, 1615-1630
   Abstract »    Full Text »    PDF »
Inhibition of Heterotrimeric G Protein Signaling by a Small Molecule Acting on G{alpha} Subunit.
M. A. Ayoub, M. Damian, C. Gespach, E. Ferrandis, O. Lavergne, O. De Wever, J.-L. Baneres, J.-P. Pin, and G. P. Prevost (2009)
J. Biol. Chem. 284, 29136-29145
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882