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PHARMACOLOGY: Hitting the Hot Spots of Cell Signaling Cascades
John Joseph Grubb Tesmer
Small-molecule inhibitors can bind in several different ways to protein interaction sites on signaling proteins, thereby selecting downstream pathways. This type of targeting may be useful therapeutically.
The author is in the Department of Pharmacology, Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109, USA. E-mail: tesmerjj{at}umich.edu
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