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Science 312 (5772): 377-378

Copyright © 2006 by the American Association for the Advancement of Science

PHARMACOLOGY:
Hitting the Hot Spots of Cell Signaling Cascades

John Joseph Grubb Tesmer

Small-molecule inhibitors can bind in several different ways to protein interaction sites on signaling proteins, thereby selecting downstream pathways. This type of targeting may be useful therapeutically.


The author is in the Department of Pharmacology, Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109, USA. E-mail: tesmerjj{at}umich.edu


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Peptide Inhibitors Disrupt the Serotonin 5-HT2C Receptor Interaction with Phosphatase and Tensin Homolog to Allosterically Modulate Cellular Signaling and Behavior.
N. C. Anastasio, S. R. Gilbertson, M. J. Bubar, A. Agarkov, S. J. Stutz, Y. Jeng, N. M. Bremer, T. D. Smith, R. G. Fox, S. E. Swinford, et al. (2013)
J. Neurosci. 33, 1615-1630
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Inhibition of Heterotrimeric G Protein Signaling by a Small Molecule Acting on G{alpha} Subunit.
M. A. Ayoub, M. Damian, C. Gespach, E. Ferrandis, O. Lavergne, O. De Wever, J.-L. Baneres, J.-P. Pin, and G. P. Prevost (2009)
J. Biol. Chem. 284, 29136-29145
   Abstract »    Full Text »    PDF »

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