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Science 312 (5776): 1008-1009

Copyright © 2006 by the American Association for the Advancement of Science

Gatekeeper at the Synapse

Harold L. Atwood

Motor neurons innervate muscles through structures containing calcium channels and vesicles poised to release transmitter. A newly described protein organizes these structures.

The author is in the Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada. E-mail: h.atwood{at}

G-proteins modulate invertebrate synaptic calcium channel (LCav2) differently from the classical voltage-dependent regulation of mammalian Cav2.1 and Cav2.2 channels.
X. Huang, A. Senatore, T. F. Dawson, Q. Quan, and J. D. Spafford (2010)
J. Exp. Biol. 213, 2094-2103
   Abstract »    Full Text »    PDF »
TRPV1 acts as a synaptic protein and regulates vesicle recycling.
C. Goswami, N. Rademacher, K.-H. Smalla, V. Kalscheuer, H.-H. Ropers, E. D. Gundelfinger, and T. Hucho (2010)
J. Cell Sci. 123, 2045-2057
   Abstract »    Full Text »    PDF »
Transient and Big Are Key Features of an Invertebrate T-type Channel (LCav3) from the Central Nervous System of Lymnaea stagnalis.
A. Senatore and J. D. Spafford (2010)
J. Biol. Chem. 285, 7447-7458
   Abstract »    Full Text »    PDF »
Frequenin/NCS-1 and the Ca2+-channel {alpha}1-subunit co-regulate synaptic transmission and nerve-terminal growth.
J. S. Dason, J. Romero-Pozuelo, L. Marin, B. G. Iyengar, M. K. Klose, A. Ferrus, and H. L. Atwood (2009)
J. Cell Sci. 122, 4109-4121
   Abstract »    Full Text »    PDF »
LAR, liprin {alpha} and the regulation of active zone morphogenesis.
E. Stryker and K. G. Johnson (2007)
J. Cell Sci. 120, 3723-3728
   Abstract »    Full Text »    PDF »
Non-NMDA-Type Glutamate Receptors Are Essential for Maturation But Not for Initial Assembly of Synapses at Drosophila Neuromuscular Junctions..
A. Schmid, G. Qin, C. Wichmann, R. J. Kittel, S. Mertel, W. Fouquet, M. Schmidt, M. Heckmann, and S. J. Sigrist (2006)
J. Neurosci. 26, 11267-11277
   Abstract »    Full Text »    PDF »

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