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Science 312 (5777): 1150-1151

Copyright © 2006 by the American Association for the Advancement of Science

Bacteria Seize Control by Acetylating Host Proteins

Carolyn A. Worby and Jack E. Dixon

The plague-causing bacterium Yersinia pestis injects toxic proteins into its hosts' cells. One of these interferes with the host's secretion of a protective factor by adding acetyl groups to a signaling kinase, blocking its activation.

The authors are in the Departments of Pharmacology, Cellular and Molecular Medicine, and Chemistry and Biochemistry, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. E-mail: jedixon{at}

Silencing of Host Cell CYBB Gene Expression by the Nuclear Effector AnkA of the Intracellular Pathogen Anaplasma phagocytophilum.
J. C. Garcia-Garcia, K. E. Rennoll-Bankert, S. Pelly, A. M. Milstone, and J. S. Dumler (2009)
Infect. Immun. 77, 2385-2391
   Abstract »    Full Text »    PDF »
Metabolism, cytoskeleton and cellular signalling in the grip of protein N{epsilon} - and O-acetylation.
X.-J. Yang and S. Gregoire (2007)
EMBO Rep. 8, 556-562
   Abstract »    Full Text »    PDF »

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