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Science 312 (5780): 1606-1608

Copyright © 2006 by the American Association for the Advancement of Science

Discriminating Microbe from Self Suffers a Double Toll

Christopher C. Goodnow

The autoimmune disease lupus is caused by immune cells that secrete antibodies to the patient's own antigens. A mouse version of the disease reveals two genes that lead to this disregulation.

The author is in the John Curtin School of Medical Research and Australian Phenomics Facility, The Australian National University, Post Office Box 334, Canberra, ACT 0200, Australia. E-mail: chris.goodnow{at}

Taxol Increases the Amount and T Cell Activating Ability of Self-Immune Stimulatory Multimolecular Complexes Found in Ovarian Cancer Cells.
N. Tsuda, D. Z. Chang, T. Mine, C. Efferson, A. Garcia-Sastre, X. Wang, S. Ferrone, and C. G. Ioannides (2007)
Cancer Res. 67, 8378-8387
   Abstract »    Full Text »    PDF »
BAFF and MyD88 signals promote a lupuslike disease independent of T cells.
J. R. Groom, C. A. Fletcher, S. N. Walters, S. T. Grey, S. V. Watt, M. J. Sweet, M. J. Smyth, C. R. Mackay, and F. Mackay (2007)
J. Exp. Med. 204, 1959-1971
   Abstract »    Full Text »    PDF »

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