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Science 312 (5781): 1752-1753

Copyright © 2006 by the American Association for the Advancement of Science

Gene Expression Needs a Break to Unwind Before Carrying On

Jean-François Haince, Michèle Rouleau, Guy G. Poirier

The molecular events that change a quiescent gene within compacted chromatin into one actively transcribing RNA are not yet clear. Unexpectedly, enzymes that create and repair DNA breaks seem to be necessary.

The authors are in the Health and Environment Unit, Faculty of Medicine, Laval University Medical Research Center, 2705 Boulevard Laurier, Quebec City, QC, G1V 4G2, Canada. E-mail: guy.poirier{at}

The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing.
J. E. Deweese and N. Osheroff (2009)
Nucleic Acids Res. 37, 738-748
   Abstract »    Full Text »    PDF »
Nuclear protein-induced bending and flexing of the hypoxic response element of the rat vascular endothelial growth factor promoter.
J. F. Breit, K. Ault-Ziel, A.-B. Al-Mehdi, and M. N. Gillespie (2008)
FASEB J 22, 19-29
   Abstract »    Full Text »    PDF »
Genomic Maintenance: The p53 Poly(ADP-ribosyl)ation Connection.
R. Alvarez-Gonzalez (2007)
Sci. STKE 2007, pe68
   Abstract »    Full Text »    PDF »

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