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TRANSCRIPTION: Gene Expression Needs a Break to Unwind Before Carrying On
Jean-François Haince, Michèle Rouleau, Guy G. Poirier
The molecular events that change a quiescent gene within compacted chromatin into one actively transcribing RNA are not yet clear. Unexpectedly, enzymes that create and repair DNA breaks seem to be necessary.
The authors are in the Health and Environment Unit, Faculty of Medicine, Laval University Medical Research Center, 2705 Boulevard Laurier, Quebec City, QC, G1V 4G2, Canada. E-mail: guy.poirier{at}crchul.ulaval.ca
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In Science Magazine
REPORTS
Bong-Gun Ju, Victoria V. Lunyak, Valentina Perissi, Ivan Garcia-Bassets, David W. Rose, Christopher K. Glass, and Michael G. Rosenfeld (23 June 2006) Science312 (5781), 1798.
[DOI: 10.1126/science.1127196] |Abstract »|Full Text »|PDF »|Supporting Online Material »