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Science 312 (5781): 1756-1758

Copyright © 2006 by the American Association for the Advancement of Science

CELL SIGNALING:
A New Way to Burn Fat

Jaap G. Neels and Jerrold M. Olefsky

Acetyl-CoA carboxylase controls fat storage and utilization in adipose cells. An important regulator of this enzyme modulates its degradation and is a potential therapeutic target for treatment of insulin resistance and obesity.


The authors are in the Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0673, USA. E-mail: jolefsky{at}ucsd.edu


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Aldo-keto Reductase Family 1 B10 Affects Fatty Acid Synthesis by Regulating the Stability of Acetyl-CoA Carboxylase-{alpha} in Breast Cancer Cells.
J. Ma, R. Yan, X. Zu, J.-M. Cheng, K. Rao, D.-F. Liao, and D. Cao (2008)
J. Biol. Chem. 283, 3418-3423
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