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Science 313 (5783): 52-53

Copyright © 2006 by the American Association for the Advancement of Science

Stressed Cells Cope with Protein Overload

David Ron

Stress on eukaryotic cells causes build-up of unfolded proteins in the endoplasmic reticulum. To protect itself, the cell degrades mRNA for ER proteins.

The author is at the Skirball Institute, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA. E-mail: ron{at}

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