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Science 313 (5785): 305-306

Copyright © 2006 by the American Association for the Advancement of Science

A New RNA Dimension to Genome Control

Richard W. Carthew

The discovery of small RNAs, microRNA and siRNA, has revolutionized thinking about the control of gene expression. Now a third new species of small RNA is shown to control gene expression in germline cells.

The author is in the Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL 60208, USA. E-mail: r-carthew{at}

Profiling Sex-Specific piRNAs in Zebrafish.
X. Zhou, Z. Zuo, F. Zhou, W. Zhao, Y. Sakaguchi, T. Suzuki, T. Suzuki, H. Cheng, and R. Zhou (2010)
Genetics 186, 1175-1185
   Abstract »    Full Text »    PDF »
Altered dynein-dependent transport in piRNA pathway mutants.
C. Navarro, S. Bullock, and R. Lehmann (2009)
PNAS 106, 9691-9696
   Abstract »    Full Text »    PDF »
MicroRNA: basic mechanisms and transcriptional regulatory networks for cell fate determination.
F. Fazi and C. Nervi (2008)
Cardiovasc Res 79, 553-561
   Abstract »    Full Text »    PDF »
aubergine Gene Overexpression in Somatic Tissues of auberginesting Mutants Interferes With the RNAi Pathway of a yellow Hairpin dsRNA in Drosophila melanogaster.
V. Specchia, C. Benna, G. M. Mazzotta, A. Piccin, M. A. Zordan, R. Costa, and M. P. Bozzetti (2008)
Genetics 178, 1271-1282
   Abstract »    Full Text »    PDF »
piRNABank: a web resource on classified and clustered Piwi-interacting RNAs.
S. Sai Lakshmi and S. Agrawal (2008)
Nucleic Acids Res. 36, D173-D177
   Abstract »    Full Text »    PDF »
Carbodiimide-mediated cross-linking of RNA to nylon membranes improves the detection of siRNA, miRNA and piRNA by northern blot.
G. S. Pall, C. Codony-Servat, J. Byrne, L. Ritchie, and A. Hamilton (2007)
Nucleic Acids Res. 35, e60
   Abstract »    Full Text »    PDF »
Review of the Application of RNA Interference Technology in the Pharmaceutical Industry.
H. M. Martineau and I. T. Pyrah (2007)
Toxicol Pathol 35, 327-336
   Abstract »    Full Text »    PDF »
Eukaryotic regulatory RNAs: an answer to the 'genome complexity' conundrum.
K. V. Prasanth and D. L. Spector (2007)
Genes & Dev. 21, 11-42
   Abstract »    Full Text »    PDF »

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