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Science 313 (5788): 767-768

Copyright © 2006 by the American Association for the Advancement of Science

When F-actin Becomes Too Much of a Good Thing

Michael L. Dustin

An excess of a protein that regulates actin assembly in white blood cells unexpectedly kills the cell by altering mitochondrial function.

The author is in the Progam in Molecular Pathogenesis, Skirball Institute, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA. E-mail: dustin{at}

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882