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Science 313 (5795): 1902-1903

Copyright © 2006 by the American Association for the Advancement of Science

Restless T Cells Sniff and Go

Tomas Mustelin

How a key immunological regulator prevents autoimmune disease has been unclear. Live imaging shows that it may prevent immune cells from lingering too long in the lymph nodes.

The author is in the Program on Inflammatory Disease Research, Infectious and Inflammatory Disease Center, and in the Program of Signal Transduction, Cancer Center, The Burnham Institute for Medical Research, La Jolla, CA 92037, USA. E-mail: tmustelin{at}

Rab8 Binding to Immune Cell-Specific Adaptor LAX Facilitates Formation of trans-Golgi Network-Proximal CTLA-4 Vesicles for Surface Expression.
M. C. Banton, K. L. Inder, E. Valk, C. E. Rudd, and H. Schneider (2014)
Mol. Cell. Biol. 34, 1486-1499
   Abstract »    Full Text »    PDF »
Murine regulatory T cells differ from conventional T cells in resisting the CTLA-4 reversal of TCR stop-signal.
Y. Lu, H. Schneider, and C. E. Rudd (2012)
Blood 120, 4560-4570
   Abstract »    Full Text »    PDF »
A CD26-Controlled Cell Surface Cascade for Regulation of T Cell Motility and Chemokine Signals.
Z. Liu, M. Christensson, A. Forslow, I. De Meester, and K.-G. Sundqvist (2009)
J. Immunol. 183, 3616-3624
   Abstract »    Full Text »    PDF »
{alpha}1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice.
E. C. Lewis, M. Mizrahi, M. Toledano, N. DeFelice, J. L. Wright, A. Churg, L. Shapiro, and C. A. Dinarello (2008)
PNAS 105, 16236-16241
   Abstract »    Full Text »    PDF »

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