Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 314 (5798): 428-429

Copyright © 2006 by the American Association for the Advancement of Science

Protein Synthesis and Oncogenesis Meet Again

Nahum Sonenberg and Arnim Pause

A protein degradation process targets a factor that blocks protein synthesis and inhibits tumor growth. Enhanced degradation of this protein may provide a growth advantage to cancer cells.

The authors are in the Department of Biochemistry and McGill Cancer Centre, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, Canada H3G 1Y6. E-mail: nahum.sonenberg{at}; arnim.pause{at}

Skeletal muscle protein synthesis and the abundance of the mRNA translation initiation repressor PDCD4 are inversely regulated by fasting and refeeding in rats.
S. Zargar, T. S. Moreira, H. Samimi-Seisan, S. Jeganathan, D. Kakade, N. Islam, J. Campbell, and O. A. J. Adegoke (2011)
Am J Physiol Endocrinol Metab 300, E986-E992
   Abstract »    Full Text »    PDF »
4E-BP1 is a target of Smad4 essential for TGF{beta}-mediated inhibition of cell proliferation.
R. Azar, A. Alard, C. Susini, C. Bousquet, and S. Pyronnet (2009)
EMBO J. 28, 3514-3522
   Abstract »    Full Text »    PDF »
Phosphoinositide 3-kinases as a common platform for multi-hormone signaling.
E. Hirsch, C. Costa, and E. Ciraolo (2007)
J. Endocrinol. 194, 243-256
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882