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Science 314 (5804): 1402-1403

Copyright © 2006 by the American Association for the Advancement of Science

Tools to Tamper with Phosphoinositides

Stuart McLaughlin

Rapidly depleting or elevating specific phosphoinositide lipids in the plasma membrane reveals their role in controlling cellular processes.

The author is in the Department of Physiology, Stony Brook University, Stony Brook, NY 11794-8661, USA. E-mail smclaughlin{at}

Transient receptor potential channels meet phosphoinositides.
B. Nilius, G. Owsianik, and T. Voets (2008)
EMBO J. 27, 2809-2816
   Abstract »    Full Text »    PDF »
Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion.
J. Liou, M. Fivaz, T. Inoue, and T. Meyer (2007)
PNAS 104, 9301-9306
   Abstract »    Full Text »    PDF »
Membrane-permeable Calmodulin Inhibitors (e.g. W-7/W-13) Bind to Membranes, Changing the Electrostatic Surface Potential: DUAL EFFECT OF W-13 ON EPIDERMAL GROWTH FACTOR RECEPTOR ACTIVATION.
P. Sengupta, M. J. Ruano, F. Tebar, U. Golebiewska, I. Zaitseva, C. Enrich, S. McLaughlin, and A. Villalobo (2007)
J. Biol. Chem. 282, 8474-8486
   Abstract »    Full Text »    PDF »

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