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Science 315 (5809): 199-200

Copyright © 2007 by the American Association for the Advancement of Science

Amplified Silencing

David C. Baulcombe

Small RNA molecules that silence gene expression are amplified by different mechanisms in nematodes and plants.

The author is in the Sainsbury Laboratory, John Innes Centre, Norwich NR4 7UH, UK. E-mail: david.baulcombe{at}

Binding and processing of small dsRNA molecules by the class 1 RNase III protein encoded by sweet potato chlorotic stunt virus.
I. Weinheimer, K. Boonrod, M. Moser, M. Wassenegger, G. Krczal, S. J. Butcher, and J. P. T. Valkonen (2014)
J. Gen. Virol. 95, 486-495
   Abstract »    Full Text »    PDF »
Distinct RNA-dependent RNA polymerases are required for RNAi triggered by double-stranded RNA versus truncated transgenes in Paramecium tetraurelia.
S. Marker, A. Le Mouel, E. Meyer, and M. Simon (2010)
Nucleic Acids Res. 38, 4092-4107
   Abstract »    Full Text »    PDF »
The role of small non-coding RNAs in genome stability and chromatin organization.
J. C. van Wolfswinkel and R. F. Ketting (2010)
J. Cell Sci. 123, 1825-1839
   Abstract »    Full Text »    PDF »
RNA-Dependent RNA Polymerase 1 from Nicotiana tabacum Suppresses RNA Silencing and Enhances Viral Infection in Nicotiana benthamiana.
X.-B. Ying, L. Dong, H. Zhu, C.-G. Duan, Q.-S. Du, D.-Q. Lv, Y.-Y. Fang, J. A. Garcia, R.-X. Fang, and H.-S. Guo (2010)
PLANT CELL 22, 1358-1372
   Abstract »    Full Text »    PDF »
Hairpin RNA induces secondary small interfering RNA synthesis and silencing in trans in fission yeast.
F. Simmer, A. Buscaino, I. C. Kos-Braun, A. Kagansky, A. Boukaba, T. Urano, A. R. W. Kerr, and R. C. Allshire (2010)
EMBO Rep. 11, 112-118
   Abstract »    Full Text »    PDF »
Identification of an RNA-dependent RNA polymerase in Drosophila involved in RNAi and transposon suppression.
C. Lipardi and B. M. Paterson (2009)
PNAS 106, 15645-15650
   Abstract »    Full Text »    PDF »
Elimination of antiviral defense by viral RNase III.
W. J. Cuellar, J. F. Kreuze, M.-L. Rajamaki, K. R. Cruzado, M. Untiveros, and J. P. T. Valkonen (2009)
PNAS 106, 10354-10358
   Abstract »    Full Text »    PDF »
Inhibition of 3' modification of small RNAs in virus-infected plants require spatial and temporal co-expression of small RNAs and viral silencing-suppressor proteins.
R. Lozsa, T. Csorba, L. Lakatos, and J. Burgyan (2008)
Nucleic Acids Res. 36, 4099-4107
   Abstract »    Full Text »    PDF »
Biochemical Activities of Arabidopsis RNA-dependent RNA Polymerase 6.
J. Curaba and X. Chen (2008)
J. Biol. Chem. 283, 3059-3066
   Abstract »    Full Text »    PDF »
Protease Activity, Self Interaction, and Small Interfering RNA Binding of the Silencing Suppressor P1b from Cucumber Vein Yellowing Ipomovirus.
A. Valli, G. Dujovny, and J. A. Garcia (2008)
J. Virol. 82, 974-986
   Abstract »    Full Text »    PDF »
Recovery of Nicotiana benthamiana Plants from a Necrotic Response Induced by a Nepovirus Is Associated with RNA Silencing but Not with Reduced Virus Titer.
J. Jovel, M. Walker, and H. Sanfacon (2007)
J. Virol. 81, 12285-12297
   Abstract »    Full Text »    PDF »

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