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Science 315 (5812): 605-606

Copyright © 2007 by the American Association for the Advancement of Science

beta-Arrestin, a Two-fisted Terminator

Eileen F. Grady

beta-arrestin escorts enzymes to activated receptors, catalyzing the demise of signals that are generated. This may be a common theme among G protein-coupled receptors.

The author is at the UCSF Center for the Neurobiology of Digestive Disease, University of California, San Francisco, CA 94143, USA. E-mail: gradye{at}

Deficiency of Phospholipase A2 Group 7 Decreases Intestinal Polyposis and Colon Tumorigenesis in ApcMin/+ Mice.
C. Xu, E. C. Reichert, T. Nakano, M. Lohse, A. A. Gardner, M. P. Revelo, M. K. Topham, and D. M. Stafforini (2013)
Cancer Res. 73, 2806-2816
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SAP-Mediated Inhibition of Diacylglycerol Kinase {alpha} Regulates TCR-Induced Diacylglycerol Signaling.
G. Baldanzi, A. Pighini, V. Bettio, E. Rainero, S. Traini, F. Chianale, P. E. Porporato, N. Filigheddu, R. Mesturini, S. Song, et al. (2011)
J. Immunol. 187, 5941-5951
   Abstract »    Full Text »    PDF »

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