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Science 315 (5813): 776-777

Copyright © 2007 by the American Association for the Advancement of Science

CELL BIOLOGY:
Cellular Demolition and the Rules of Engagement

Richard J. Youle

Does cell death occur by pulling the plug on Bcl-2 life support or pulling the trigger on Bax activation?


The author is in the Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. E-mail: youler{at}ninds.nih.gov


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
BIM and tBID Are Not Mechanistically Equivalent When Assisting BAX to Permeabilize Bilayer Membranes.
O. Terrones, A. Etxebarria, A. Landajuela, O. Landeta, B. Antonsson, and G. Basanez (2008)
J. Biol. Chem. 283, 7790-7803
   Abstract »    Full Text »    PDF »
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis.
M. Nguyen, R. C. Marcellus, A. Roulston, M. Watson, L. Serfass, S. R. Murthy Madiraju, D. Goulet, J. Viallet, L. Belec, X. Billot, et al. (2007)
PNAS 104, 19512-19517
   Abstract »    Full Text »    PDF »

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Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)