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Science 315 (5813): 776-777

Copyright © 2007 by the American Association for the Advancement of Science

Cellular Demolition and the Rules of Engagement

Richard J. Youle

Does cell death occur by pulling the plug on Bcl-2 life support or pulling the trigger on Bax activation?

The author is in the Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. E-mail: youler{at}

Mediation of the Antiapoptotic Activity of Bcl-xL Protein upon Interaction with VDAC1 Protein.
N. Arbel, D. Ben-Hail, and V. Shoshan-Barmatz (2012)
J. Biol. Chem. 287, 23152-23161
   Abstract »    Full Text »    PDF »
The BH3 {alpha}-Helical Mimic BH3-M6 Disrupts Bcl-XL, Bcl-2, and MCL-1 Protein-Protein Interactions with Bax, Bak, Bad, or Bim and Induces Apoptosis in a Bax- and Bim-dependent Manner.
A. Kazi, J. Sun, K. Doi, S.-S. Sung, Y. Takahashi, H. Yin, J. M. Rodriguez, J. Becerril, N. Berndt, A. D. Hamilton, et al. (2011)
J. Biol. Chem. 286, 9382-9392
   Abstract »    Full Text »    PDF »
BclxL Changes Conformation upon Binding to Wild-type but Not Mutant p53 DNA Binding Domain.
F. Hagn, C. Klein, O. Demmer, N. Marchenko, A. Vaseva, U. M. Moll, and H. Kessler (2010)
J. Biol. Chem. 285, 3439-3450
   Abstract »    Full Text »    PDF »
Bax Activates Endophilin B1 Oligomerization and Lipid Membrane Vesiculation.
T. K. Rostovtseva, H. Boukari, A. Antignani, B. Shiu, S. Banerjee, A. Neutzner, and R. J. Youle (2009)
J. Biol. Chem. 284, 34390-34399
   Abstract »    Full Text »    PDF »
KLF6-SV1 Is a Novel Antiapoptotic Protein That Targets the BH3-Only Protein NOXA for Degradation and Whose Inhibition Extends Survival in an Ovarian Cancer Model.
A. DiFeo, F. Huang, J. Sangodkar, E. A. Terzo, D. Leake, G. Narla, and J. A. Martignetti (2009)
Cancer Res. 69, 4733-4741
   Abstract »    Full Text »    PDF »
BIM and tBID Are Not Mechanistically Equivalent When Assisting BAX to Permeabilize Bilayer Membranes.
O. Terrones, A. Etxebarria, A. Landajuela, O. Landeta, B. Antonsson, and G. Basanez (2008)
J. Biol. Chem. 283, 7790-7803
   Abstract »    Full Text »    PDF »
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis.
M. Nguyen, R. C. Marcellus, A. Roulston, M. Watson, L. Serfass, S. R. Murthy Madiraju, D. Goulet, J. Viallet, L. Belec, X. Billot, et al. (2007)
PNAS 104, 19512-19517
   Abstract »    Full Text »    PDF »

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