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Science 316 (5822): 208-210

Copyright © 2007 by the American Association for the Advancement of Science

The Sources of a Lipid Conundrum

Jerold Chun

Distinct sources of a bioactive lipid are needed for lymphocytes to enter the circulation. Therapeutic strategies need to take into account the existence of more than one lipid reservoir.

The author is at the Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. E-mail: jchun{at}

Immunosuppressive human anti-lymphocyte autoantibodies specific for the type 1 sphingosine 1-phosphate receptor.
J.-J. Liao, M.-C. Huang, K. Fast, K. Gundling, M. Yadav, J. R. Van Brocklyn, M. R. Wabl, and E. J. Goetzl (2009)
FASEB J 23, 1786-1796
   Abstract »    Full Text »    PDF »
Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2.
H. Ikeda, N. Watanabe, I. Ishii, T. Shimosawa, Y. Kume, T. Tomiya, Y. Inoue, T. Nishikawa, N. Ohtomo, Y. Tanoue, et al. (2009)
J. Lipid Res. 50, 556-564
   Abstract »    Full Text »    PDF »
The lysophospholipid mediator sphingosine-1-phosphate promotes angiogenesis in vivo in ischaemic hindlimbs of mice.
O. Oyama, N. Sugimoto, X. Qi, N. Takuwa, K. Mizugishi, J. Koizumi, and Y. Takuwa (2008)
Cardiovasc Res 78, 301-307
   Abstract »    Full Text »    PDF »

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