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Science 316 (5824): 550-551

Copyright © 2007 by the American Association for the Advancement of Science

Getting Closer to the Whole Picture

Uwe Sauer, Matthias Heinemann, Nicola Zamboni

A quantitative data set of RNA, proteins, and metabolites provides an unprecedented starting point to understand, at a systems level, the effects of perturbations on a cell.

The authors are at the Institute of Molecular Systems Biology, ETH Zurich, Switzerland. E-mail: sauer{at}

Comprehensive quantitative analysis of central carbon and amino-acid metabolism in Saccharomyces cerevisiae under multiple conditions by targeted proteomics.
R. Costenoble, P. Picotti, L. Reiter, R. Stallmach, M. Heinemann, U. Sauer, and R. Aebersold (2014)
Mol Syst Biol 7, 464
   Abstract »    Full Text »    PDF »
Tradeoff between enzyme and metabolite efficiency maintains metabolic homeostasis upon perturbations in enzyme capacity.
S.-M. Fendt, J. M. Buescher, F. Rudroff, P. Picotti, N. Zamboni, and U. Sauer (2014)
Mol Syst Biol 6, 356
   Abstract »    Full Text »    PDF »
Mass Spectrometry-based Workflow for Accurate Quantification of Escherichia coli Enzymes: How Proteomics Can Play a Key Role in Metabolic Engineering.
M. Trauchessec, M. Jaquinod, A. Bonvalot, V. Brun, C. Bruley, D. Ropers, H. de Jong, J. Garin, G. Bestel-Corre, and M. Ferro (2014)
Mol. Cell. Proteomics 13, 954-968
   Abstract »    Full Text »    PDF »
Mapping Condition-Dependent Regulation of Lipid Metabolism in Saccharomyces cerevisiae.
M. C. Jewett, C. T. Workman, I. Nookaew, F. A. Pizarro, E. Agosin, L. I. Hellgren, and J. Nielsen (2013)
g3 3, 1979-1995
   Abstract »    Full Text »    PDF »
Systems biology of Ewing sarcoma: a network model of EWS-FLI1 effect on proliferation and apoptosis.
G. Stoll, D. Surdez, F. Tirode, K. Laud, E. Barillot, A. Zinovyev, and O. Delattre (2013)
Nucleic Acids Res. 41, 8853-8871
   Abstract »    Full Text »    PDF »
An Integrated Clinico-Metabolomic Model Improves Prediction of Death in Sepsis.
R. J. Langley, E. L. Tsalik, J. C. v. Velkinburgh, S. W. Glickman, B. J. Rice, C. Wang, B. Chen, L. Carin, A. Suarez, R. P. Mohney, et al. (2013)
Science Translational Medicine 5, 195ra95
   Abstract »    Full Text »    PDF »
Global Network Reorganization During Dynamic Adaptations of Bacillus subtilis Metabolism.
J. M. Buescher, W. Liebermeister, M. Jules, M. Uhr, J. Muntel, E. Botella, B. Hessling, R. J. Kleijn, L. Le Chat, F. Lecointe, et al. (2012)
Science 335, 1099-1103
   Abstract »    Full Text »    PDF »
Exhaled breath condensate: metabolomics.
S. Carraro, G. Giordano, M. Stocchero, and E. Baraldi (2010)
Exhaled Biomarkers 231-236
   Abstract »    Full Text »    PDF »
Biological knowledge management: the emerging role of the Semantic Web technologies.
E. Antezana, M. Kuiper, and V. Mironov (2009)
Brief Bioinform 10, 392-407
   Abstract »    Full Text »    PDF »
Advanced Data-Mining Strategies for the Analysis of Direct-Infusion Ion Trap Mass Spectrometry Data from the Association of Perennial Ryegrass with Its Endophytic Fungus, Neotyphodium lolii.
M. Cao, A. Koulman, L. J. Johnson, G. A. Lane, and S. Rasmussen (2008)
Plant Physiology 146, 1501-1514
   Abstract »    Full Text »    PDF »

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