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Science 316 (5827): 988-989

Copyright © 2007 by the American Association for the Advancement of Science

Converging on beta-Catenin in Wilms Tumor

Roel Nusse

A common thread in some cancers is mutations in a developmental signaling pathway that ultimately affect the action of a single component.

The author is in the Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University, School of Medicine, Stanford, CA 94305-5323, USA. E-mail: rnusse{at}

Mutated {beta}-catenin evades a microRNA-dependent regulatory loop.
A. Veronese, R. Visone, J. Consiglio, M. Acunzo, L. Lupini, T. Kim, M. Ferracin, F. Lovat, E. Miotto, V. Balatti, et al. (2011)
PNAS 108, 4840-4845
   Abstract »    Full Text »    PDF »
A Novel Wilms Tumor 1 (WT1) Target Gene Negatively Regulates the WNT Signaling Pathway.
M. S. Kim, S. K. Yoon, F. Bollig, J. Kitagaki, W. Hur, N. J. Whye, Y. P. Wu, M. N. Rivera, J. Y. Park, H. S. Kim, et al. (2010)
J. Biol. Chem. 285, 14585-14593
   Abstract »    Full Text »    PDF »
An integrated genome screen identifies the Wnt signaling pathway as a major target of WT1.
M. K.-H. Kim, T. J. McGarry, P. O Broin, J. M. Flatow, A. A.-J. Golden, and J. D. Licht (2009)
PNAS 106, 11154-11159
   Abstract »    Full Text »    PDF »

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