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Science 316 (5828): 1138-1139

Copyright © 2007 by the American Association for the Advancement of Science

A Touching Response to Damage

John H. J. Petrini

An extensive network of proteins, and their combinatorial diversity, account for biological functions that are regulated in response to damaged DNA.

Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA. E-mail: petrinij{at}

Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair.
W.-C. Chou, H.-C. Wang, F.-H. Wong, S.-l. Ding, P.-E. Wu, S.-Y. Shieh, and C.-Y. Shen (2008)
EMBO J. 27, 3140-3150
   Abstract »    Full Text »    PDF »
The RAD5-dependent Postreplication Repair Pathway is Important to Suppress Gross Chromosomal Rearrangements.
K. Myung and S. Smith (2008)
J Natl Cancer Inst Monographs 2008, 12-15
   Abstract »    Full Text »    PDF »
Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1.
S. Sivasubramaniam, X. Sun, Y.-R. Pan, S. Wang, and E. Y.-H.P. Lee (2008)
Genes & Dev. 22, 587-600
   Abstract »    Full Text »    PDF »

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