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Science 317 (5835): 206-207

Copyright © 2007 by the American Association for the Advancement of Science

PI3K Charges Ahead

Jennifer Y. Lee, Jeffrey A. Engelman, Lewis C. Cantley

Structural information about an enzyme implicated in numerous cancers provides insights into to how certain mutations promote cancer cell growth and survival.

The authors are in the Department of Systems Biology, Harvard Medical School, and in the Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA. J. A. Engelman is also at Massachusetts General Hospital Cancer Center, Boston, MA 02115, USA. E-mail: lewis_cantley{at}

A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae.
O. Gallego, M. J. Betts, J. Gvozdenovic-Jeremic, K. Maeda, C. Matetzki, C. Aguilar-Gurrieri, P. Beltran-Alvarez, S. Bonn, C. Fernandez-Tornero, L. J. Jensen, et al. (2014)
Mol Syst Biol 6, 430
   Abstract »    Full Text »    PDF »
SKAP1 Protein PH Domain Determines RapL Membrane Localization and Rap1 Protein Complex Formation for T Cell Receptor (TCR) Activation of LFA-1.
M. Raab, X. Smith, Y. Matthess, K. Strebhardt, and C. E. Rudd (2011)
J. Biol. Chem. 286, 29663-29670
   Abstract »    Full Text »    PDF »
Inhibition of PI3K binding to activators by serine phosphorylation of PI3K regulatory subunit p85{alpha} Src homology-2 domains.
J. Y. Lee, Y.-H. Chiu, J. Asara, and L. C. Cantley (2011)
PNAS 108, 14157-14162
   Abstract »    Full Text »    PDF »
Targeting Epidermal Growth Factor Receptor-Associated Signaling Pathways in Non-Small Cell Lung Cancer Cells: Implication in Radiation Response.
E. J. Choi, Y. K. Ryu, S. Y. Kim, H. G. Wu, J. S. Kim, I. H. Kim, and I. A. Kim (2010)
Mol. Cancer Res. 8, 1027-1036
   Abstract »    Full Text »    PDF »

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