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Science 317 (5836): 330-331

Copyright © 2007 by the American Association for the Advancement of Science

A Ciliary Signaling Switch

Søren Tvorup Christensen and Carolyn Marie Ott

Primary cilia contain the receptor for a secreted protein crucial for cell regulation, strengthening their potential as signaling centers in the cell.

S. T. Christensen is at the Department of Molecular Biology, University of Copenhagen, Copenhagen DK-2100, Denmark. E-mail: stchristensen{at} C. M. Ott is in the Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA. E-mail: ottcarol{at}

Downregulating Hedgehog Signaling Reduces Renal Cystogenic Potential of Mouse Models.
P. V. Tran, G. C. Talbott, A. Turbe-Doan, D. T. Jacobs, M. P. Schonfeld, L. M. Silva, A. Chatterjee, M. Prysak, B. A. Allard, and D. R. Beier (2014)
J. Am. Soc. Nephrol.
   Abstract »
Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma.
S. Blotta, J. Jakubikova, T. Calimeri, A. M. Roccaro, N. Amodio, A. K. Azab, U. Foresta, C. S. Mitsiades, M. Rossi, K. Todoerti, et al. (2012)
Blood 120, 5002-5013
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Independent Analysis of the Flagellum Surface and Matrix Proteomes Provides Insight into Flagellum Signaling in Mammalian-infectious Trypanosoma brucei.
M. Oberholzer, G. Langousis, H. T. Nguyen, E. A. Saada, M. M. Shimogawa, Z. O. Jonsson, S. M. Nguyen, J. A. Wohlschlegel, and K. L. Hill (2011)
Mol. Cell. Proteomics 10, M111.010538
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Sonic Hedgehog Stimulates Proliferation of Human Periodontal Ligament Stem Cells.
C. Martinez, P. C. Smith, J. P. Rodriguez, and V. Palma (2011)
Journal of Dental Research 90, 483-488
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Identification of novel antigens with induced immune response in monoclonal gammopathy of undetermined significance.
S. Blotta, P. Tassone, R. H. Prabhala, P. Tagliaferri, D. Cervi, S. Amin, J. Jakubikova, Y.-T. Tai, K. Podar, C. S. Mitsiades, et al. (2009)
Blood 114, 3276-3284
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The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation.
C. A. Clement, S. G. Kristensen, K. Mollgard, G. J. Pazour, B. K. Yoder, L. A. Larsen, and S. T. Christensen (2009)
J. Cell Sci. 122, 3070-3082
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Roles of the Primary Cilium Component Polaris in Synchondrosis Development.
T. Ochiai, M. Nagayama, T. Nakamura, T. Morrison, D. Pilchak, N. Kondo, H. Hasegawa, B. Song, R. Serra, M. Pacifici, et al. (2009)
Journal of Dental Research 88, 545-550
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Polycystin-1 Regulates Skeletogenesis through Stimulation of the Osteoblast-specific Transcription Factor RUNX2-II.
Z. Xiao, S. Zhang, B. S. Magenheimer, J. Luo, and L. D. Quarles (2008)
J. Biol. Chem. 283, 12624-12634
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