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Science 317 (5840): 907-908

Copyright © 2007 by the American Association for the Advancement of Science

Synapses Here and Not Everywhere

David M. Miller

Local degradation of synaptic proteins determines which neuronal connections persist and which are eliminated during development.

The author is in the Department of Cell and Developmental Biology, Vanderbilt University, 465 21st Avenue South, Nashville, TN 37232-8240, USA. E-mail: david.miller{at}

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882