Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 318 (5849): 403-404

Copyright © 2007 by the American Association for the Advancement of Science

Unlocking Cell Fate

Ashley G. Rivenbark and Brian D. Strahl

Histone demethylation is associated with the activation of genes that control cellular development, differentiation, and the determination of cell fate.

The authors are in the Department of Biochemistry and Biophysics, UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. E-mail: brian_strahl{at}

Histone Demethylase Jmjd3 Regulates Osteoblast Differentiation via Transcription Factors Runx2 and Osterix.
D. Yang, H. Okamura, Y. Nakashima, and T. Haneji (2013)
J. Biol. Chem. 288, 33530-33541
   Abstract »    Full Text »    PDF »
Mass Spectrometric Studies on Epigenetic Interaction Networks in Cell Differentiation.
L. Xiong, A. Darwanto, S. Sharma, J. Herring, S. Hu, M. Filippova, V. Filippov, Y. Wang, C.-S. Chen, P. J. Duerksen-Hughes, et al. (2011)
J. Biol. Chem. 286, 13657-13668
   Abstract »    Full Text »    PDF »
Coordinated but physically separable interaction with H3K27-demethylase and H3K4-methyltransferase activities are required for T-box protein-mediated activation of developmental gene expression.
S. A. Miller, A. C. Huang, M. M. Miazgowicz, M. M. Brassil, and A. S. Weinmann (2008)
Genes & Dev. 22, 2980-2993
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882